Past Projects
Promoting Adaptive Neuroplasticity
Overview
Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment (MERIT) examines the effects of two types of treatments for memory impairment in those with mild cognitive impairment (MCI): a cognitive rehabilitation task involving new ways to learn and remember information and non-invasive brain stimulation (tDCS). tDCS can enhance functioning in brain regions associated with memory decline, thereby reinforcing the benefits of memory rehabilitation strategies. The study includes 9 visits at the University of Michigan including cognitive testing, tDCS, and functional magnetic resonance imaging (fMRI).
Eligibility Criteria
Adults age 50+
Right-handed
Official diagnosis of MCI
Stable on all medications for at least 4 weeks prior to participation
English speaking (as the preferred language)
fMRI compatible
Exclusionary Criteria
History of severe psychiatric conditions (bipolar disorder, schizophrenia, etc.)
History of other neurological conditions (epilepsy, stroke, traumatic brain injury, etc.)
Sensory impairments that limit the ability to see or hear
History of (or current) drug or alcohol use/dependence
You can read more about the Merit study on the U.S. Clinical Trials website.
Stimulation of Cingulo-Opercular Alertness Network (SCAN)
Overview
Stimulation of Cingulo-Opercular Alertness Network (SCAN) examines the use of transcranial electrical stimulation (tES) as a potential treatment for cognitive challenges in those suffering from Lewy Body Dementia. The study includes 12 visits at the University of Michigan including cognitive testing, tDCS, and functional magnetic resonance imaging (fMRI), and positron emission tomography (PET) imaging.
Eligibility Criteria
Individuals with a diagnosis of Lewy Body Dementia
50-90 years of age
Stable on doses of cholinesterase inhibitors (at least 4 weeks)
Participants must be MRI compatible (via the American College of Radiology guideline), criteria that also apply for High Definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants)
Exclusionary Criteria
Participants who cannot receive MR imaging
Participants who cannot receive tDCS (for example, but not limited to, those with a pacemaker)
Evidence of large vessel stroke or mass lesion on MRI
Use of anti-cholinergic or neuroleptic drugs
Evidence of atypical parkinsonism on neurological exam
You can read more about the SCAN study on the U.S. Clinical Trials website.
Memory Training and Neuroplasticity
Overview
The Memory Training and Plasticity (WMtrain) study aims to to better understand the effects of cognitive training as a possible method for improving cognition. This study includes between 8 and 18 visits at the University of Michigan involving cognitive testing, surveys, and functional magnetic resonance imaging (fMRI). We are recruiting older adults both with and without cognitive changes such as mild cognitive impairment.
Eligibility Criteria
60+ years old
Native English speaker
Right-handed
Exclusionary Criteria
Sensory impairments that limit the ability to see or hear
History of (or current) drug or alcohol abuse/dependence